There is a glimmer of hope that cornerback Rasul Douglas will be able to play Sunday against the Giants.
The second-year defensive back was listed as questionable on Friday's injury report with knee and ankle injuries, although he hasn't practiced all week.
Meanwhile, the Eagles will be without cornerbacks Sidney Jones (hamstring) and Jalen Mills (foot), linebacker Jordan Hicks (calf), and safety Avonte Maddox (knee, ankle). Without the three defensive backs, the Eagles will rely heavily on De'Vante Bausby, Cre'Von LeBlanc, and Chandon Sullivan.
"It's great experience. I know they are young. But it's a great opportunity for them," head coach Doug Pederson said. "We always talk about the next man, and they're the next men. They worked extremely hard this week in practice so far. It will be another great opportunity for all three of those guys really to kind of step up, really help the defense against an offense right now that's playing well. Great opportunity for those three."
Running back Darren Sproles (hamstring) is also out for the rematch with the Giants.
There is some good news. Defensive tackle Tim Jernigan will make his season debut after offseason surgery caused him to miss the first 10 games. Center Jason Kelce (elbow) and long snapper Rick Lovato (concussion) are also good to go.
For the Giants, defensive end Kerry Wynn is out with a concussion. He was the only player listed on New York's injury report all week.