Defensive end Trent Cole exited Sunday's game in the fourth quarter with a calf strain and will have an MRI on Monday morning, according to head coach Andy Reid.

Cole suffered the injury after fellow end Jason Babin recorded his third sack of the game. It was the first time an Eagles defensive player had 3.0 sacks in a game since ironically Cole did against the Lions in 2007 when he had 3.5.

Earlier in the game, defensive tackle Antonio Dixon suffered a triceps strain and also did not return. That left the Eagles with just two healthy defensive ends (Babin, Phillip Hunt) and three tackles (Mike Patterson, Cullen Jenkins and Trevor Laws) down the stretch as the 49ers powered their way with the run game to take the lead and eventually salt the game away. Dixon, like Cole, will have an MRI on Monday morning.

"It definitely hurt," Babin said of losing the two linemen. "But you know what, you've got to do what you've got to do. You've got to dig deep."

Cole has not missed a game due to injury since his rookie year of 2005.

Left tackle Jason Peters also suffered a hamstring strain which took place when wide receiver Jeremy Maclin fumbled the ball away late in the fourth quarter. He, too, will have an MRI in the morning.

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