With guard Matt Tobin already out and guard Dennis Kelly inactive, the Eagles had seven offensive linemen up for Sunday's game vs. Jacksonville.
The depth was put to the test as All-Pro guard Evan Mathis was knocked out of the game with a left knee injury incurred on a run by LeSean McCoy in the second quarter. Right tackle Allen Barbre also left the game, but with a right ankle injury. At halftime, Barbre's status was questionable to return.
Backup center David Molk went in at left guard and backup tackle Andrew Gardner went in to replace Barbre after first subbing for Mathis at left guard.
The Eagles were shutout in the first half and gained just 129 yards of offense. Quarterback Nick Foles was sacked five times and turned the ball over three times.
The Jaguars lost starting safety Johnathan Cyprien to a head injury that was incurred trying to contest a throw to wide receiver Jeremy Maclin in the second quarter.