In a pleasant surprise, defensive end Juqua Parker, who was listed as questionable with a high ankle sprain that has kept him out the last two weeks, is active and will play against the Buffalo Bills as the Eagles look to get their second win of the season. With Pro Bowl defensive end Trent Cole out, Parker's return is a boon to a defensive line that can use the depth. Along with Parker, fellow defensive end Darryl Tapp, who was listed as probable with a pectoral strain, is also active.

Defensive tackle Derek Landri, who was signed earlier this week to replace Antonio Dixon, is also active, giving the Eagles eight active defensive linemen.

The list of inactives for the Eagles is led by Cole and Pro Bowl left tackle Jason Peters, followed by offensive lineman Julian Vandervelde, cornerback Curtis Marsh, safety Jaiquawn Jarrett, quarterback Mike Kafka and offensive lineman Kyle DeVan.

With Peters out, King Dunlap will start at left tackle and Winston Justice will be active for the first time this season. First-round pick Danny Watkins will start at right guard, where DeVan started the first four games of the season.

Meanwhile, at quarterback, Kafka is inactive for the first time this season, leaving Vince Young as Michael Vick's primary backup.

The Bills will also be without a couple starters in left tackle Demetrius Bell and linebacker Chris Kelsay. Fourth-round rookie Chris Hairston will start in Bell's place. The rest of the Bills' inactives are cornerback Aaron Williams, cornerback Terrence Wheatley, linebacker Chris White, offensive guard Colin Brown and nose tackle Torrell Troup.