Another week, another new offensive line combination.

Head Coach Doug Pederson confirmed on Wednesday morning that rookie tackle Jack Driscoll suffered a knee injury in Sunday's win over New Orleans.

"He's definitely going to miss some time with the injury," Pederson said.

It is yet to be determined whether or not Driscoll will need surgery. Matt Pryor will start at right tackle in what will be the team's 13th different starting offensive line combination in 14 games. It'll be Pryor's second start at right tackle this season. He's also started six games at right guard in 2020, while filling in at left guard this season as well.

Overall, Pryor has played 549 snaps on offense. This Sunday, he'll see plenty of former Temple star Haason Reddick. The Camden, New Jersey native earned NFC Defensive Player of the Week honors for his performance on Sunday when he set a franchise record with five sacks against the Giants.

"He's quick. He's fast, agile. He can bend. Speed rusher. Obviously, he had a heck of a game the other day, so Pryor's got to get in here, study the tape and study him, and we expect him to be prepared," Pederson said.

Driscoll showed promise as a rookie. He started at right tackle in Week 1 when Lane Johnson couldn't play due to his injured ankle. Driscoll started four games in all at right tackle, playing exactly 300 total snaps on offense.