Injuries have plagued the Eagles all season long, and heading into Thursday's Thanksgiving Day meeting with the Lions the team knew it would be without running back Ryan Mathews (concussion, groin) and tight end Zach Ertz (concussion). The status of three other key members of the offense were uncertain entering the day, but 90 minutes before kickoff we were given clarity.

For the second straight game, quarterback Sam Bradford will be inactive with a concussion and injury to his non-throwing shoulder. There was hope that the first-year Eagle would be cleared to play against Detroit, with the team saying throughout the week that his status remained up in the air. In his absence, though, the team will go with Mark Sanchez behind center. Sanchez has completed 40 of his 64 passes (62.5%) in two games this season, tallying 417 yards with two touchdowns and four picks. Luckily, the Eagles will have left tackle Jason Peters (back) and center Jason Kelce (knee), both of whom were listed as questionable heading into Thursday. 

Outside of Bradford, Mathews, and Ertz, the Eagles will deactivate wide receiver Jonathan Krause, offensive lineman Tanner Hawkinson, defensive end Brandon Bair, and cornerback Denzel Rice.

The Lions enter Thursday's game with a relatively clean bill of health. Despite being listed as questionable heading into the day, wideout Calvin Johnson will play, as will cornerback Darius Slay, defensive tackle Caraun Reid, and safety Don Carey, all of whom were listed as questionable this week.

Detroit will deactivate defensive tackles Gabe Wright and Jermelle Cudjo, wide receiver TJ Jones, offensive linemen LaAdrian Waddle and Corey Robinson, safety Isaiah Johnson, and tight end Tim Wright.